Penentuan Kadar Flavonoid dan Aktivitas Anti-Inflamasi Ekstrak Dan Fraksi Daun Sungkai (Peronema canescens Jack)

Penulis

  • Desi Nadya Aulena Departement of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta, 12640, Indonesia ,
  • Dwi Fitri Yani Departement of Chemistry, Faculty of Sains and Technology, Universitas Islam Negeri Raden Fatah Palembang, South of Sumatera , 30257 , Indonesia ,
  • Mariyamah Mariyamah Departement of Chemistry, Faculty of Sains and Technology, Universitas Islam Negeri Raden Fatah Palembang, South of Sumatera , 30257 , Indonesia ,
  • Muhammad Lufika Tondi Departement of Chemistry, Faculty of Sains and Technology, Universitas Islam Negeri Raden Fatah Palembang, South of Sumatera , 30257 , Indonesia ,
  • Muhammad Dandi Departement of Chemistry, Faculty of Sains and Technology, Universitas Islam Negeri Raden Fatah Palembang, South of Sumatera , 30257 , Indonesia ,
  • Hafis Kiki Wahyudin Departement of Chemistry, Faculty of Sains and Technology, Universitas Islam Negeri Raden Fatah Palembang, South of Sumatera , 30257 , Indonesia ,
  • Dany Raihan Faculty of UBC Vantage College, University of British Colombia, Vancouver V6T 1Z4, Canada ,

DOI:

https://doi.org/10.35814/jifi.v21i2.1437

Kata Kunci:

COVID-19, denaturasi protein, inflamasi, penyakit infeksi, virus SARS-CoV2

Abstrak

Virus SARS-CoV-2 menyebabkan penyakit COVID-19, yang menyebabkan demam dan peradangan di tubuh pasien. Daun sungkai (Peronema canescens Jack) adalah salah satu tanaman herbal yang diyakini masyarakat Indonesia dapat mengatasi COVID-19. Tujuan dari penelitian ini adalah untuk mengetahui kadar flavonoid pada ekstrak (etanol, etil asetat, dan n-heksan) dan sifat antiinflamasi ekstrak etanol, fraksi etanol, dan fraksi n-heksan daun sungkai. Metode ini dilakukan secara in-vitro dengan menggunakan spektrofotometer UV-Vis untuk melihat respon serapan terhadap penghambatan denaturasi protein penyebab inflamasi. Selanjutnya, nilai inhibisi (%) terbaik ditemukan pada konsentrasi 15 ppm, yaitu fraksi etanol, ekstrak etanol, dan fraksi n-heksan, masing-masing sebesar 74,27% dan 54,4 persen. Ekstrak etanol daun sungkai memiliki kadar flavonoid tertinggi sebesar 38.782 g/mL.

Referensi

Unduhan

Diterbitkan

2023-10-16

Terbitan

Vol 21 No 2 (2023): JIFI

Bagian

Articles

Lisensi

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