Cytotoxic Activity of Benalu Batu (Begonia sp.) Methanolic Extract: An Ethnomedicine of Wana Tribe Central Sulawesi

Authors

  • MUHAMMAD SULAIMAN ZUBAIR UNIVERSITAS TADULAKO ,
  • SYARIFUL ANAM UNIVERSITAS TADULAKO ,
  • YULIET . UNIVERSITAS TADULAKO ,
  • AGUS RITNA UNIVERSITAS TADULAKO ,
  • FIRMANITA DWIMURTI UNIVERSITAS TADULAKO ,
  • DEWI RISMAYANTI UNIVERSITAS TADULAKO ,

Keywords:

Begonia sp, cytotoxic, HeLa, T47D, methanol extract, MTT

Abstract

Benalu batu (Begonia sp.) is used as traditional medicine by Wana tribe in Central Sulawesi to treat various diseases, including cancer. In an effort to search potential anticancer drugs from natural sources, investigation was conducted on the cytotoxic activity of Begonia sp. methanol extract against cervic cancer cells (HeLa) and breast cancer cells (T47D) and identification of the chemical compound groups in methanol extract that is responsible for the anticancer activity. Investigations including the extraction of Begonia sp. dried herb by soxhletation using methanol, followed by evaporation on rotary vapor until viscous extract gained. The cytotoxic test were carried out by tetrazolium bromide (MTT) method. The concentration series of Begonia sp. methanol extract were 250, 125, 62.5 and 31.25 μg /mL. Results showed that the Begonia sp. methanol extract inhibited the growth of cervic cancer cells (HeLa) (IC50 = 70.97 μg/mL) stronger than inhibition on breast cancer cells (T47D) (IC50 = 122.21 μg/mL). Analysis of chemical compound groups in the methanol extract using thin-layer chromatography (TLC) method indicated that polyphenolic flavonoid might be the main compound responsible for the anticancer activity

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Published

2018-01-25

Issue

Vol. 12 No. 1 (2014): JIFI

Section

Articles

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