Gastroprotective Activity of Combination of Neem (Azadirachta indica A. Juss) Bark and Turmeric (Curucuma domestica Linn.) Rhizome Extracts on Rats Induced by Acetosal

Authors

  • SANTI PUMA SARI UNIVERSITAS INDONESIA ,
  • ABDUL MUN’IM UNIVERSITAS INDONESIA ,
  • DINI KUSUMANINGTYAS UNIVERSITAS INDONESIA ,

Keywords:

Azadirachta indica, Curcuma domestica, neem bark, turmeric, gastric ulcer, gastroprotective, acetosal

Abstract

Some pre-clinical and clinical studies reported that neem (Azadirachta indica A. Juss) bark and turmeric (Curcuma domestica Linn.) rhizome extracts demonstrated strong gastroprotective activities. In this studies, the effect of combination of neem bark and turmeric rhizome extracts were investigated on acetosal-induced gastric ulcer in rats.The combination is expected to produce synergic effect on the gastric ulcer. The combination of extracts was administered orally in various doses for 7 days prior to the ulcer induction. On the 8th-day rats were given asetosal 400 mg/kg bw to induce gastric ulcer. All rats were sacrificed 8 hours after asetosal induction for the determination of ulcer index, total acidity, mucus thickness and histophatological examination. The combination of neem bark extract (250 mg/kg bw) and turmeric rhizome extract (50 mg/kg bw) was significantly reduced the ulcer index (a = 0.05). This result was substantiated by histophatological examinations. Results of this study showed that combination of neem bark and turmeric rhizome extracts have synergic gastroprotective activities.

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Published

2013-09-30

Issue

Vol. 11 No. 2 (2013): JIFI

Section

Articles

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