Isolation and Identification of Bioactive Compound of Aceton Extract Garcinia lateriflora Blume Leaf

Authors

  • SRI HARTATI LEMBAGA ILMU PENGETAHUAN INDONESIA ,
  • DEDE RAHMAWATI UNIVERSITAS PANCASILA ,
  • SUJASWADI WIRYOWIDAGDO UNIVERSITAS PANCASILA ,

Keywords:

Garcinia lateriflora BL., asaron, murine P388, Artemia salina L.

Abstract

Preliminary studies have been carried out phytochemical test acetone leaf extract Garcinia
lateriflora Blume., and toxicity test against shrimp larvae (Artemia salina Leach) and murine cell line
P388. Isolates which showed the highest mortality are proceeded further for fractionation, isolation and
purification. The structure identification of active campound carriedout by analyzing the spectrum of IR ,
GC-MS (Gas chromatography mass spectrometer) and proton nuclear magnetic resonance spectrometer
(1H-NMR ) and (13C-NMR ). The results showed that the most active against the larval shrimp Artemia
salina L. with LC50 value of 18.03 ug/mL is b-asaron, IC50 of test results on cell line murine P-388 is 47.0
ug/mL. This compound was isolated first time from the plant Garcinia lateriflora BL.

References

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Published

2011-09-30

Issue

Vol. 9 No. 2 (2011): JIFI

Section

Articles

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