Immunomodulatory Activity of Several Plants from Piperaceae Family in Balb/C Mice with Carbon Clerance Method

Authors

  • Mohammad Roseno Poltekkes Kemenkes Bandung ,
  • Yayat Sudaryat Jurusan Farmasi, Politeknik Kesehatan Kemenkes Bandung ,
  • Widyastiwi Widyastiwi Jurusan Farmasi, Politeknik Kesehatan Kemenkes Bandung ,

DOI:

https://doi.org/10.35814/jifi.v17i2.558

Keywords:

kemukus (Piper cubeba), cabe jawa (Piper retrofractum), kiseureuh (Piper aduncum), imunomodulator, carbon clearance

Abstract

Plants of Piperaceae family are widespread in the tropics region and have been widely used as medicinal plants, these includes kemukus (Piper cubeba), kiseureuh (Piper aduncum), and Java chili (Piper retrofractum). The purpose of this study was to evaluate the immunomodulatory activity of ethanol extracts of several plants from the Piperaceae family in Balb/C strain mice with carbon clearance method. The study was conducted by dividing the experimental animals into 12 groups : normal control group, immunosuppressant comparison, immunostimulant comparison, and low, moderate, and high dose of kemukus, kiseureuh, and Java chili, resepctively. Immunomodulatory activity was measured by phagocytosis index, peripheral blood leukocyte levels, and splenic leukocyte levels. The results showed that ethanol kemukus extract (Piper cubeba) acts as an immunosuppressant, increasing the dose increased the immunosuppressant effect. Low doses of ethanol extract of kiseureh (Piper aduncum) also acts as  immunosuppressant, whereas at medium and high doses has a tendency to be immunostimulant. Ethanol extract of Java chili (Piper retrofractum) acts as an immunostimulant, with the highest activity achieved at moderate doses. Ethanol extract of kemukus (Piper cubeba), kiseureh (Piper aduncum), and Java chili (Piper retrofractum) affect the number of peripheral blood granulocyte components, neutrophils levels affects the increase in phagocytic effects. Ethanol extract of kemukus (Piper cubeba), kiseureh (Piper aduncum), and Java chili (Piper retrofractum) did not affect the number of splenic blood granulocyte components.

 

References

Downloads

Published

2019-10-29

Issue

Vol. 17 No. 2 (2019): JIFI

Section

Articles

License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.