The Study of Blood Creatinin and Urea Concentration of Wistar Rats (Rattus norvegicus) due to Sodium Nitrite Induction

Authors

  • Dyah Ayu Widyastuti Pendidikan Biologi Universitas PGRI Semarang ,
  • Maria Asih Ristianti Universitas Gadjah Mada ,
  • Ika Maya Sari Universitas Gadjah Mada ,

DOI:

https://doi.org/10.35814/jifi.v17i1.560

Keywords:

creatinin, sodium nitrite, urea

Abstract

Sodium nitrite is one of common food addition in most meat product. This kind of food preservative is allowed by Permenkes No. 722/Menkes/Per/IX/88 only in minimum doses due to its carcinogenic effect. The most targeted organ is kidney which is sensitive to chemical matter as nefrotoxin. When the kidney is damaged, the erytropoietin secretion to form erytrocite is disturbed. Physiological damage in kidney can be identified by the concentration of blood creatinin and urea. The objective of this research is to study about blood creatinin and urea concentration of Wistar rats which is induced by sodium nitrite. Two groups of Wistar rats were induced by two doses of sodium nitrite (11.25 and 22.50 mg/kg body weight, respectively) a day with one group of control. Blood serum of those three groups were then be analyzed for creatinin and urea concentration each week for three months. The result showed that creatinin concertration is fluctuative during the day one to day ninety. The average of creatinin concentration for two treated groups is not significantly lower than control group. Generally, the urea concentration is increasing for day fourteen to seventy seven then decreasing in day eighty four to ninety. However, there are no significant differences among three groups.

References

Downloads

Published

2019-04-24

Issue

Vol. 17 No. 1 (2019): JIFI

Section

Articles

License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.