Penghambatan Ekspresi Gen dengan Antisense Oligonukleotida sebagai Upaya Pengobatan Penyakit

Authors

  • Dian Ratih Laksmitawati Universitas Pancasila ,
  • Ani Retno Prijanti Fakultas Kedokteran Universitas Indonesia ,

Keywords:

oligonucleotide, antisense, gene expression, therapy

Abstract

Due to the development of biomolecular science eg. overexpression genes, genes that cause diseases can be identfied, Based on this fact, researchers developed a therapeutic strategy by inhibiting the gene expression using oligonucleotide antisense. Therapy using oligonucleotide antisense was based on a natural process of gene expression. Specific artificial antisense will match complementary with DNA and mRNA. By this process the transcription will stop. The effort of therapy is relatively new but a few have been carried out in the clinical trial phase. Obstacles are encountered in reaching the target cell by the oligonucleotide antisense.

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Issue

Vol. 3 No. 2 (2005): JIFI

Section

Articles

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