The Importance of Protein Binding in Drug Monitoring

Authors

  • Aluwi Nirwana Sani Universitas Pancasila ,

Keywords:

ikatan obat-protein, monitoring obat, konsentrasi obat tidak terikat, konsentrasi obat total

Abstract

Ikatan obat dengan protein dalam darah umumnya tidak mempengaruhi efek terapinya. Selama tidak ada pergeseran ikatan, akibat obat lain yang afinitasnya lebih besar terhadap protein atau perubahan kondisi pasien. Terjadinya pergeseran ikatan yang mengakibatkan peningkatan konsentrasi obat tidak terikat juga akan dikompensasi dengan peningkatan volume distribusi sehingga konsentrasi obat tidak terikat kembali normal. Akan tetapi dalam prosedur monitoring obat yang ditetapkan adalah konsentrasi oba total, sehingga salah interprestasi bisa terjadi.

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Issue

Vol. 2 No. 2 (2004): JIFI

Section

Articles

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