Eugenol Effect of Clove Flower (Syzygium Aromaticum) Isolate on Histology Pancreas of Diabetic Rat

Authors

  • Sinta Wahyu Utami Fakultas Kedokteran, Fakultas MIPA Universitas Mataram ,
  • I Made Sudarma Fakultas Kedokteran, Fakultas MIPA Universitas Mataram ,
  • Candra Dwipayana Hamdin Fakultas Kedokteran, Fakultas MIPA Universitas Mataram ,

DOI:

https://doi.org/10.35814/jifi.v17i2.694

Keywords:

Clove flower, eugenol, antidiabetic, pancreatic histology

Abstract

Diabetes mellitus is disease with a high prevalence rate and continuously increase in Indonesia. So some researchers began to glance at natural rescource for prevention and treatment of diabetes mellitus. Clove Flower (Syzygium aromaticum) contains eugenol that can chemically lower blood sugar levels. The aimed of this research is to know the effect  of eugenol on pancreas histology of diabetic rats. Clove flowers was extracted used maseration method  use n-hexan and eugenol was isolated tested with TLC. Alloxan-induced rats were dosed 125 mg / kg BW IP and then the eugenol was administered in  dosage 10 mg / kg BW compared with glibenclamid 1,35 mg /Kg BW orally for 14 days. Observation of pancreatic histology results were made pancreatic preparations using Hematoxilin Eosin (HE) staining. The results showed that alloxan-induced rats had pancreatic cell damage. How ever, after being treated with Glibenclamide and Eugenol showed the improvement of damage organs. Giving the eugenol at a dose of 15 mg / kg BW showed the most significant improvement.

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Published

2019-10-29

Issue

Vol. 17 No. 2 (2019): JIFI

Section

Articles

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