Anti–Platelet Aggregation and Anti-Inflamatory Eff ect from Ethanol Extract Of Tembelekan Leaves (Lantana Camara Linn.) In Vivo

Abstract

Atherosclerosis is chronic inflammatory disease that can be prevented with anti-inflammatory
activity agents and reduce thrombus formation in blood vessels. Tembelekan leaves (Lantana camara
Linn.) contain fl avonoids, saponins, and essential oils which potential to inhibit platelet aggregation and
be anti-inflammatory. This study aimed to test the in vivo anti-platelet aggregation and anti-inflammatory
activity of tembelekan leaves. Platelet anti-aggregation test was carried out on mice by assessing the
decrease in plasma absorbance after addition of ADP. Mice were divided into normal group, positive
control group which was given clopidogrel and 3 test groups which were given Tembelekan leaf extract
at a dose of 2.5, 5, 10 g/kgBW. In vivo anti-inflammatory test used the Winter method with intraplantar
1% carrageenan as inducer. There was a signifi cant decrease in plasma absorbance after addition of
ADP at doses of 2.5 and 5 g/kgBW of tembelekan leaves i.e 5.47% and 12.28% compared to the
normal group. Positive control and dose of 10 g/kgBW gave the same eff ect. In anti-inflammatory
test, the doses of 3.2 and 6.4 g/kgBW of tembelekan leaves gave percentage value of inhibition which
was not signifi cantly diff erent with diclofenac sodium. Tembelekan leaves potentially as anti-platelet
aggregation and anti-inflammatory properties.