Isolation and Identification of Phenolic Compounds from Macaranga hispida Blume Mull.Arg Leaves

Authors

  • Megawati Megawati Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,
  • Sofa Fajriah Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,
  • Galuh Widyawati Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,
  • Akhmad Darmawan Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,

DOI:

https://doi.org/10.35814/jifi.v18i2.722

Keywords:

Macaranga hispida, phenolic compounds, gallic acid, methyl gallate, cytotoxicity

Abstract

Continuation of research on Macaranga plant has been conducted. In this study, the total
phenol content (TPC) of Macaranga hispida Blume Mull. Arg leaves extracts were investigated. Gallic
acid (1) and methyl gallate (2) have been isolated from the ethyl acetate fraction which highest phenolic
content (8.41 mg GAE/g). Serial techniques of chromatographic and spectroscopic methods, namely
extraction, fractionation, purifi cation, FTIR, LCMS, and FT-NMR were used to isolate and identify the
isolates. Cytotoxicity of compound 1 and 2 against P-388 cell line showed that compound 2 has higher
anticancer activity compared to compound 1 with IC50 value of 75.53 μg/mL.

References

Downloads

Published

2020-10-28

Issue

Vol. 18 No. 2 (2020): JIFI

Section

Articles

License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.