In Vitro Antiinflammatory Activity of Etlingera elatior (Jack) R.M. Smith by Hrbc Membrane Stabilization Method

Authors

  • Adryan Fristiohady Fakultas Farmasi, Universitas Halu Oleo
  • Wahyuni Wahyuni Fakultas Farmasi, Universitas Halu Oleo ,
  • Fadhliyah Malik Fakultas Farmasi, Universitas Halu Oleo ,
  • Nurjeddah Fariane Fakultas Farmasi, Universitas Halu Oleo ,
  • Muhammad Ilyas Y. Program Studi DIII Analis Kesehatan, Politeknik Bina Husada Kendari ,
  • Mentarry Bafadal Fakultas Farmasi, Universitas Halu Oleo ,
  • Sahidin F. Fakultas Farmasi, Universitas Halu Oleo ,

DOI:

https://doi.org/10.35814/jifi.v18i2.731

Keywords:

Antiinflammatory, wualae, red blood cell membrane

Abstract

Wualae (Etlingera elatior (Jack) R. M. Smith) is plant that traditionally used as traditional medicine in Southeast Sulawesi. It contains fl avonoids, tannins, and terpenoids that act as anti-infl ammatory. The studyaims to investigate the anti-infl ammatory activity of ethanolic extract of wualae by stabilizing human red bloodcell (HRBC) membrane. Hemolysis and stability due to oxidative induction and hypotonic solutes are used asmeasures of anti-infl ammatory activity. The positive controls used in this study were diclofenac sodium withvarious concentrations of 250 ppm; 500 ppm; 750 ppm; 1000 ppm; 1250 ppm; and 1500 ppm. Sample wasalso having similar identical concentration. According to the results of stability and hemolysis percentage ofE. elatior fruit ethanol extract to HRBC were 57,75% and 42,25% (250 ppm), 66,71% and 33,29% (500 ppm),74,10% and 25,90% (750 ppm), 75,72% and 24,28% (1000 ppm), 79,87% and 20,13% (1250 ppm), and 84,89%and 15,11% (1500 ppm). Compared with diclofenac sodium stability and hemolysis percentage were 62,61%and 37,39% (250 ppm), 66,71% and 33,29% (500 ppm), 71,02% and 28,98% (750 ppm), 72,10% and 27,90%(1000 ppm), 73,94% and 26,06% (1250 ppm), 76,63% and 23,37% (1500 ppm). These data suggest that the ethanolic extract of wualae is potentially have activity as anti-infl ammatory.

References

Downloads

Published

2020-10-28

Issue

Vol. 18 No. 2 (2020): JIFI

Section

Articles

License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.