Antimalarial Activity of Multiple Dose and Single Dose Administration of Artocarpus Champeden Spreng. Stembark Extract on Plasmodium Berghei Infected Mice

Authors

  • SOFIANA SARI UNIVERSITAS AIRLANGGA ,
  • ACHMAD FUAD HAFID UNIVERSITAS AIRLANGGA ,
  • ATY WIDYAWARUYANTI UNIVERSITAS AIRLANGGA ,

Keywords:

Artocarpus champeden, multiple dose, single dose, antimalarial, Plasmodium berghei

Abstract

 Artocarpus champeden Spreng. (Moraceae) known as “cempedakâ€, was traditionally used for antimalarial remedies in Indonesia. Study to determine antimalarial activity of ethanol extract of cempedak stembark was carried out. Artocarpus champeden Ethanol Extract (ACEE) was administered twice per day (multiple dose) and once per day (single dose) orally. The study was carried out by modification method of the “4 Days Suppressive Test†originally described by Peter. The result showed that ACEE administered twice per day inhibited parasites growth (ED 0.19 mg/kg BW) higher than once per day (ED 6.0 mg/kg BW) and 10 mg/kg body weight of dose administrated twice per day was more effective than 100 mg/kg body weight once per day. 

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Published

2015-04-30

Issue

Vol. 13 No. 1 (2015): JIFI

Section

Articles

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