Formulation of a peel-off gel mask containing mundu fruit extract (Garcinia dulcis (roxb.) kurz) for antioxidant and anti-elastase activity

Abstract

The skin serves as a protective barrier against ultraviolet (UV) radiation. However, exposure to UV radiation can lead to various skin problems, including changes in the dermis. To prevent UV-induced damage, antioxidants and anti-elastase agents are needed to protect the skin from oxidative stress. This study aims to evaluate the antioxidant and anti-elastase activities of Mundu fruit extract (Garcinia dulcis (Roxb.) Kurz) and to formulate a peel-off gel mask using the concentrated extract. Antioxidant activity was assessed using the FRAP and ABTS methods, while anti-elastase activity was determined by measuring the release of p-nitroaniline from a substrate degraded by the elastase enzyme. The results showed that the IC₅₀ value for antioxidant activity using the ABTS method is 29.57 ppm  0.72, and the FRAP value was 185.02  10.23 AAE/g. The anti-elastase activity showed IC₅₀  of 82.21 ppm. Three peel-off gel mask formulations were developed, with Formula 3 (containing extract at 200 x IC₅₀₎. showing the best performance. These findings suggest that the thick Mundu fruit extract, which tested positive for phenolic compounds, exhibits promising antioxidant and anti-elastase activities and is suitable for use in topical formulations.