Design, Synthesis and Citotoxicity Assay of UK-3A analogue: Hydroxypicolinil Dioctyl Glutamic Ester

Authors

  • YULIA ANITA LEMBAGA ILMU PENGETAHUAN INDONESIA ,
  • MUHAMMAD HANAFI LEMBAGA ILMU PENGETAHUAN INDONESIA ,

Keywords:

cytotoxic, UK-3A, P388, cells, 3-hydroxypicolinyl dioctyl glutamate ester

Abstract

Antibiotic UK 3A had been isolated as a minor component from the mycelium of Streptomyces sp. 517-0. It was elucidated as a nine-member dilactone ring derivative. To produce an analog of UK-3A, i.e. hydroxypicolinil dioctyl glutamic ester, was synthesized from L glutamic acid and octanol, and the product was then reacted with 3-hydroxypicolinic acid and dioctyl glutamic ester. The tinal product was identified by 1H and 13C FT NMR, FT-IR spectrophotometry, and LC-MS. The it was tested for cytotoxic activity against P388 Murine Leukemia cells. The results showed that the 3-hydroxypicolinyl dioctyl glutamic ester has higher inhibition activity against P388 leukemia cells with IC50 value of 9.80 µg/mL than the activity of UK 3A with IC50 value of 38.4 µg/mL.

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Published

2011-04-30

Issue

Vol. 9 No. 1 (2011): JIFI

Section

Articles

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