Cytotoxicity and Antioxidant Activity Tests on T yphonium divuricatum (L) Decne Leaves

Authors

  • YUNAHARA FARIDA UNIVERSITAS PANCASILA ,
  • TITIEK MARTATI UNIVERSITAS PANCASILA ,
  • AHMAD MUSIR UNIVERSITAS PANCASILA ,
  • BERNARD EDWARD UNIVERSITAS PANCASILA ,

Keywords:

Typhonium divaricatum (L) Decne, BSLT, Cytotoxic activity, T-47D, MTT, DPPH

Abstract

Cytotoxic and antioxidant activities of Typhonium divaricatum (L) Decne leaves extract have been explored. Preliminary phytocheinical screening on the extract were carried out for the compound`s profile. Biological activity was measured by using Brine Shrimp Lethality Test (BSLT), while cytotoxic activity was conducted on breast cancer cell line T-47D using MTT method, Antioxidant activity was measured by using DPPH free radical scavenging method. The results of phytochemical screening showed that the methanol extract contained Havonoid, saponin and steroid/triterpenoid compounds, meanwhile thc n-hexane extract contained steroid/triterpenoid compounds only. The highest biological activity was found in methanol extract (IC50 = 32.9 ppm). The highest cytotoxic activity was shown by n-hexane extract (IC50 = 32.50 ppm). The highest antioxidant activity using vitamin C as positive control was found in methanol extract (IC50 = 56.63 ppm). The preliminary results indicated that Typhonium divaricatum (L) Decne lcavcs is potential for anticancer and free radical scavenger.

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Published

2010-09-30

Issue

Vol. 8 No. 2 (2010): JIFI

Section

Articles

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