Isolation and Identification of Chemical Compounds as Anticancer from Leaves of Kopasanda (Chromolaena odorata (L.))

Authors

  • MUHAMMAD FITRAH UNIVERSITAS ISLAM NEGERI MAKASAR ,
  • HENDIG WINARNO UNIVERSITAS PANCASILA ,
  • PARTOMUAN SIMANJUNTAK UNIVERSITAS PANCASILA ,

Keywords:

kopasanda leaves, Chromolaena odorata L, antioxidant, antiproliferation

Abstract

Isolation and identifi cation of chemical compound as anticancer from the leaves of Kopasanda (Chromolaena odorata L.) had been done. Extraction was conducted successfully with n-hexane, ethylacetate and ethanol by maceration, and by refl ux for water solvent. Fractionation of ethylacetate extract by column chromatography (SiO2). n-hexane-ethylacetate = 10:1 ~ 1:1; ethylacetate). n-hexaneethylacetate = 5:1) gave one pure isolated fraction fr. 5-3 with inhibition activity against leukemia cell line L1210 at concentration 1.515 ppm. Chemical structure determination was done based on spectral data interpretation of Infra Red, 1D NMR (1H, 13C) and 2D NMR (H-H COSY, HMQC and HMBC) and mass spectra (LC-MS). Pure isolated fraction fr. 5-3 was deducted as methyl ether naragenine.

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Published

2017-04-30

Issue

Vol. 15 No. 1 (2017): JIFI

Section

Articles

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