Efek Kurkumin terhadap Aktivitas Enzim Glutation Peroksidase Mitokondria Hati Tikus

Authors

  • Syamsudin Syamsudin Universitas Pancasila ,
  • Suyatna FD Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia ,
  • Ganiswarna S Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia ,
  • Sadikin M Bagian Biokimia Fakultas Kedokteran Universitas Indonesia ,

Keywords:

gluthatione peroxidase, t-BHP, Curcumin, mitochondria

Abstract

This study was conducted to prove the hypothesis that Curcumin could prevent the oxidative damage of rat liver mitochondria induced by t-butylhydroperoxide (t-BHP). The induction of 400 uMt-BHP reduced Gluthatione Peroxidase (GPx) activity from (0.29+0.03) to (0.04+0.01) umol/min/mg protein. Instillation of Curcumin of 1000 uM could elevate GPx activity to (0.16+0.002) umol/min/mg protein.

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Issue

Vol. 2 No. 2 (2004): JIFI

Section

Articles

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