Toksisitas dan Anti-inflamasi Senyawa 1,5-Bis(3’-Etoksi-4’-Hidroksifenil)-1,4- Pentadien-3-on (EHP)

Penulis

  • ESTI MUMPUNI UNIVERSITAS PANCASILA ,
  • LESTARI RAHAYU UNIVERSITAS PANCASILA ,
  • ARIEF NURROCHMAD UNIVERSITAS PANCASILA ,

Kata Kunci:

toksisitas, anti-inflammatory, EHP

Abstrak

Senyawa 1,5-bis(3’-etoksi-4’-hidroksifenil)-1,4-pentadien-3-on (EHP) adalah senyawa analog kurkumin, telah disintesis sebelumnya dengan metode kondensasi aldol dan terbukti mempunyai aktivitas antioksidan lebih tinggi daripada kurkumin. Telah dilakukan uji keamanan bahan calon obat meliputi uji toksisitas (LD50) dengan metode Weil C.S. dan uji aktivitas antiinflamasi secara in vivo. Nilai LD50 dari senyawa EHP adalah sebesar 6,8675 g/kg BB dengan kriteria toksik ringan sehingga cukup aman sebagai calon bahan obat. Aktivitas anti-inflamasi senyawa EHP diaanalisis dengan mengukur derajat bengkak pada kaki tikus. Hasil uji efek anti-inflamasi EHP dosis 137,35 mg, 274,70 mg dan 549,40 mg sama dengan aspirin 90 mg/200 g BB.

Referensi

Unduhan

Terbitan

Vol 13 No 1 (2015): JIFI

Bagian

Articles

Lisensi

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