Formulasi Tablet Mukoadesif Ekstrak Etanol Daun Mangga Bapang (Mangifera indica L. ‘Bapang’) sebagai Antidiabetes Menggunakan Matriks Guar Gum
Kata Kunci:
mucoadhesive tablets, antidiabetic, mango leaves, guar gumAbstrak
Ekstrak etanol daun mangga bapang (Mangifera indica L. ‘Bapang’) diketahui mengandung mangiferin yang mempunyai aktivitas antidiabetes pada pasien diabetes melitus. Penelitian ini bertujuan untuk ndaatkan ua tat ktak tan daun ana aan an nui aat iat ik tablet dan mengetahui pengaruh variasi penambahan matriks guar gum terhadap sifat mukoadesif tablet. Tablet dibuat menggunakan metode granulasi basah yang memvariasikan kadar guar gum sebagai atik iadi at diui iat ikna dan daa ukadina diui caa in vitro menggunakan alat silinder berputar dan diamati selama 8 jam. Hasil penelitian menunjukkan bahwa tablet ekstrak tan daun ana aan unai kaaktitik ik an nui aat iat ik tat i mukoadesif secara in vitro menunjukkan bahwa semua formula tablet memiliki daya mukoadesif yang bagus. Daya mukoadesif meningkat seiring meningkatnya guar gum. Hasil penelitian menunjukkan formula 4 dengan kadar guar gum paling tinggi memiliki daya mukoadesif yang paling besar yaitu dapat melekat selama 7±1 jam.
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