Ethanolic extract of Parkia speciosa Hassk leaves innovation of gastroretentive tablet: standardization and optimization
DOI:
https://doi.org/10.35814/jifi.v23i2.1461Kata Kunci:
Extract, gastroretentive, phytopharmaceutics, screening phytochemistry, Parkia SpeciosaAbstrak
Parkia speciosa ethanol leaves extract contains flavonoid, tanin, and terpen as ulcus peptic remedy. Formulation of gastroretentive extract Parkia speciose (EPS) with floating-mucoadhesive system aims to control prolonged release of drugs in stomach to increase bioavailability. The preparation of gastrorententive tablet was formulated by variety concentration of HPMC-K4M and chitosan with sodium bicarbonate as gas generating system. Tablets were made by wet granulation method, i.e. ratio of the concentration of HPMC-K4M and chitosan in F1 (10% : 5%), FA(25% : 5%), FB (10% : 20%), and FAB (25% : 20%). Tablets were evaluated for hardness, friability, floating lag time,floating duration time, swelling index, and mucoadhesive time of drug with design factorial. The result is: high concentration of chitosan were able to increase hardness,friability, floating lag time, and mucoadhesive time, while the high concentration of HPMC-K4M increased friability, swelling index and decrease of floating lag time. Result of factorial design showed optimum area (overlay plot) with comparison of polymers. HPMC-K4M (20.25 %) : chitosan (10.26 %) were able to give maximum evaluation, which includes, friability 0.22 %, hardness 29.53 N, mucoadhesive time 22.86 hours, floating duration time 12 hours, floating lag time 27.54 minutes, and swelling index 312.82%
Referensi
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