Uji Iritasi Sediaan Gel Penyembuh Luka Ekstrak Etanol Daun Binahong Menggunakan Slug Irritation Test

Penulis

  • SRI HARTATI YULIANI UNIVERSITAS SANATA DHARMA ,
  • YUMI RAHMADANI PT GENARO PHARMACEUTICALS ,
  • ENADE PERDANA ISTYASTONO UNIVERSITAS SANATA DHARMA ,

Kata Kunci:

gel penyembuh luka, ekstrak etanol daun binahong, slug irritation test

Abstrak

Wound healing is a complex of various dynamic processes which are not completely understood. There are 3 phases in the normal wound healing, i.e. inflammation phase, tissue formation phase and tissue remodeling phase. The duration of the inflammation phase takes an important part of the healing process. The prolonged inflammation will delay the healing process. Irritant can lead prolonged elevation of interleukin-1 and TNF-α. It causes the degradation of extracellular matrix that is an important material for tissue formation. Wound dressing should not contain irritant material. Therefore, all wound dressing have to be tested for skin irritation potency. Wound healing gel of ethanolic extract of binahong leaf has been tested for its irritant potency by slug irritation test. The validation of slug irritation test resulted both of sensitivity and specificity 100% at the cut-off mucus production of 8.79%. This method was valid to determine irritant potency of the product. Mucus production of the gel was 4.55%, therefore it can be concluded that the gel did not cause skin irritation.

Referensi

Unduhan

Diterbitkan

2017-09-04

Terbitan

Vol 14 No 2 (2016): JIFI

Bagian

Articles

Lisensi

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