Pemodelan Farmakokinetika Tablet Floating Aspirin pada Kelinci dengan PKSolver

Penulis

  • AGUS SISWANTO UNIVERSITAS MUHAMMADIYAH PURWOKERTO ,
  • ACHMAD FUDHOLI UNIVERSITAS GADJAH MADA ,
  • AKHMAD KHARIS NUGROHO UNIVERSITAS GADJAH MADA ,
  • SUDIBYO MARTONO UNIVERSITAS GADJAH MADA ,

Kata Kunci:

PKSolver, multiple absorption site, tablet floating aspirin

Abstrak

Aspirin is an effective analgesic which is also used as an antiplatelet therapy for stroke prophylaxis. Aspirin is rapidly absorbed in the upper gastrointestinal tract, especially in the first of the small intestine. Formulation of floating drug delivery system are designed to improve the bioavailability of aspirin. The aim of this study was to determine pharmacokinetic model of floating tablets of aspirin in rabbits with PKSolver. PKSolver was used to evaluate the models based on the parameters: 1) visual goodness of fit (GOF), and 2) statistical criteria including the Akaike Information Criterion (AIC) and the Schwarz criterion (SC). Both the GOF and statistical criteria evaluations indicated multiple absorption site model as the best model describing pharmacokinetic of aspirin floating tablet. The release and absorption of aspirin floating tablet occurs through two phases resulting pharmacokinetic profile with a double peak due to absorption occur in parallel in the stomach.

Referensi

Unduhan

Diterbitkan

2017-09-04

Terbitan

Vol 14 No 2 (2016): JIFI

Bagian

Articles

Lisensi

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