Sintesis Analog 3-0-Benzylstentorin sebagai Prekursor untuk Kerangka Dasar Blepharismin

Penulis

  • TENI ERNAWATI LEMBAGA ILMU PENGETAHUAN INDONESIA ,
  • YOSHINOSUKE USUKI FACULTY OF SCIENCE OSAKA CITY UNIVERSITY ,
  • HIDEO IIO FACULTY OF SCIENCE OSAKA CITY UNIVERSITY ,

Kata Kunci:

blepharismin, 3-0-benzilstentorin, sintesis, dimerisasi, turunan antrakuinon

Abstrak

Metode sintesis prekursor untuk kerangka dasar dan struktural analog blepharismin telah dijelaskan. Senyawa tersebut diidentifikasi sebagai obat yang potensial untuk pengobatan terapi antivirus dan photodynamic. Analog benzil stentorin sebagai kerangka dasar blepharismin secara efektif disintesis melalui reaksi antara salah satu gugus hidroksil senyawa biantrakuinon dengan p-metoksi benzyl klorida dengan adanya kalium karbonat sebagai basa. Dimerisasi senyawa turunan bromo antrakuinon menghasilkan produk dimmer sebesar 55% sedangkan untuk pembentukan senyawa analog 3-0-benzylstentorin diperoleh rendemen hasil 70%.

Referensi

Unduhan

Diterbitkan

2012-04-30

Terbitan

Vol 10 No 1 (2012): JIFI

Bagian

Articles

Lisensi

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