Formulasi Serum sebagai Penyembuh Luka Bakar Berbahan Baku Utama Serbuk Konsentrat Ikan Gabus (Channa striatus)

Penulis

  • SITI MARDIYANTI UNIVERSITAS INDONESIA ,
  • EFFIONORA ANWAR UNIVERSITAS INDONESIA ,
  • FADLINA CHANY SAPUTRI UNIVERSITAS INDONESIA ,

Kata Kunci:

serum, gelasi ionik, ikan gabus (Channa striatus), kitosan, natrium tripolipospat, luka bakar derajat dua, histologi

Abstrak

Snakehead fish (Channa striatus) has been reported can be used for wound healing because contains high amount of protein, essential amino acids and fatty acids that influenced wound healing. This study was performed to formulate serum for burn wound healing contain concentrate powder of snakehead fish (Channa striatus) have been made with gelation ionic using chitosan and sodium tripolyphosphate as an active substances. Concentrate powder of snakehead fish with concentration 7.5% (formula 1), 10% (formula 2) and 12.5% (formula 3). And then formulated to serum using collagen and gelatin as thickening agent. Serum has been formulated, characterized and evaluated in vivo for burn wound healing second degree (deep partial thickness) on rabbits. Suspense and also serums has been characterized by physicochemical. The results showed that nanoparticle suspenses (formula 1, formula 2 and formula 3) have particle size in range 42.67-204.23 nm, 70.81-257.11 nm, 128.86-323.68 nm; zeta potential (+) 16.9 mV, (+) 18.3 mV, (+) 18.4 mV; all of formulas have sferichal particles. In vivo study and analized histology showed that serums from powder concentrate of snakehead fish and chitosan-tripolyphosphate have burn wound healing second degree (deep partial thickness) effect.

Referensi

Unduhan

Diterbitkan

2017-09-04

Terbitan

Vol 14 No 2 (2016): JIFI

Bagian

Articles

Lisensi

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