Formulasi dan Uji Penetrasi In-Vitro Sediaan Topikal Nanoemulsi Genistein dari Tanaman Sophora japonica Linn

Penulis

  • SANDRA AULIA MARDIKASARI UNIVERSITAS INDONESIA ,
  • MAHDI JUFRI UNIVERSITAS INDONESIA ,
  • JOSHITA DJAJADISASTRA UNIVERSITAS INDONESIA ,

Kata Kunci:

Nanoemulsion, genistein, penetration study, Franz diffusion cell

Abstrak

The purpose of this study was to prepared genistein in nanoemulsion and compared its penetration with Gen90 Nano. There was 3 types of formula with composition ratio between genistein and soy lecithin using a spontaneous emulsification methods. The results showed that formula 3 was the chosen formula which has 191,7 nm particle size, 0,171 polydispersity index and -47,5 mV zeta potential. In-vitro penetration study using Franz diffusion cell showed that amount cumulative in penetration of genistein nanoemulsion was 18,29 ± 0,16 (μg/cm2) compared with Gen90 Nano was 24,60 ± 0,57 (μg/cm2). This comparison was done to see the quality of penetration of genistein nanoemulsion formula, because Gen90 Nano was a patent product consist of Genistein - Hydroxypropyl Cyclodextrin (HPCD) inclusion complex.

Referensi

Unduhan

Diterbitkan

2017-09-04

Terbitan

Vol 14 No 2 (2016): JIFI

Bagian

Articles

Lisensi

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