Isolasi Senyawa Aktif dari Ekstrak Hipokotil Sarang Semut (Myrmecodia pendens Merr. & Perry) sebagai Penghambat Xantinoksidase

Penulis

  • PARTOMUAN SIMANJUNTAK LEMBAGA ILMU PENGETAHUAN INDONESIA ,
  • FANNY FANNY LEMBAGA ILMU PENGETAHUAN INDONESIA ,
  • MUHAMMAD AHKAM SUBROTO LEMBAGA ILMU PENGETAHUAN INDONESIA ,

Kata Kunci:

sarang semut, Myrmecodia pendens, Rubiaceae, xanthin oxidase inhibitor

Abstrak

Medicinal plant called “sarang semutâ€, Myrmecodia pendens Merr. & Perry (Rubiaceae), is an epiphyt plant traditionally used in Papua for healing various diseases such as hyperuricemia, rheumatic, and cancer. A chemical compound recognized as xanthinoxidase inhibitor has been isolated from n-buthanol fraction of the plant extract. The isolation was carried out by column chromatography (SiO2, CHCI3-MeOH = 5:1-1:1) and the purification Was conducted using high pressure liquid chromatography (RP, C-18; MeOH-water = 5 : 1). The activity test for Xanthinoxidase inhibitor Was performmed by using modilied Noro method. The pure compound showed xanthinoxidase inhibitor activity of IC50  at 79,77%.

Referensi

Unduhan

Diterbitkan

2010-04-30

Terbitan

Vol 8 No 1 (2010): JIFI

Bagian

Articles

Lisensi

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