Formulasi Sediaan Tablet Ekstrak Sambung Nyawa (Gynurae procumbens (Lour).Merr) sebagai Kandidat Antidiabetes

Abstrak

Sambung nyawa leaf extract (Gynura procumbens (Lour.) Merr.) which have in vitro efficacious as antidiabetic that it can inhibit the enzyme α-glucosidase. This study aims to formulate a 70% ethanol extract of sambung nyawa leaves into a tablet dosage form that meets the quality parameters of physical and in vivo tests. Condensed extract of sambung nyawa leaves is formulated into 3 formulas with variations of filler: dibasic calcium phosphate (Formula I), lactose (Formula II) and microcrystalline cellulose (Formula III) by wet granulation method. Furthermore, the formula tested α-glucosidase inhibition, a formula which has the most activity tested in vivo. The results of physical evaluation of all formulas: organoleptic is green, bitter taste and distinctive smell; average weight uniformity: 510.26; 506.61 and 508.08 mg; tablet hardness: 6.2, 5.6 and 5.2%; friability: 0.14, 0.13 and 0.15%; desintegration time: 6 minutes 50 seconds, 7 minutes and 49 seconds and 7 minutes 39 seconds and inhibitory activity of α-glucosidase enzyme: 76.35, 67.13 and 78.14%. In this test, acarbose is used as a positive control with % inhibition is 88.49%. It can be concluded that physical quality tablet of all formulas are within the acceptable standard and is able to inhibit the enzyme α-glucosidase. Formula III is the most active. The results of in-vivo test on the 14th day after the administration at a dose tablet use 3x2 tablet per day can lower blood glucose levels.