Isolasi dan Identifi kasi Senyawa Kimia Zat Anti Kanker dari Daun Kopasanda (Chromolaena odorata (L.))

Penulis

  • MUHAMMAD FITRAH UNIVERSITAS ISLAM NEGERI MAKASAR ,
  • HENDIG WINARNO UNIVERSITAS PANCASILA ,
  • PARTOMUAN SIMANJUNTAK UNIVERSITAS PANCASILA ,

Kata Kunci:

daun kopasanda, Chromolaena odorata L, antiproliferasi, antioksidan

Abstrak

Isolasi dan identifi kasi senyawa kimia sebagai antikanker dari daun Kopasanda (Chromolaena odorata L.) telah dilakukan. Ekstraksi dilakukan secara berturut-turut dengan n-heksan, etilasetat, dan etanol secara maserasi kecuali dengan air dilakukan secara refl uks. Fraksinasi ekstrak etilasetat dengan kromatografi kolom (SiO2,: i). n-heksan-etilasetat = 10:1 ~ 1:1; etilasetat, ii). n-heksan-etilasetat = 5:1) memberikan satu isolat murni fr. 5-3 yang mempunyai aktivitas daya hambat terhadap sel leukemia L1210 sebesar 1,515 bpj. Penentuan struktur kimia dilakukan berdasarkan interpretasi data spektra infra merah, RMI 1D (1H, 13C) dan RMI 2D (H-H COSY, HMQC dan HMBC) dan spektra masa (LC-MS). Isolat fr. 5-3 diduga adalah metil eter naragenin.

Referensi

Unduhan

Diterbitkan

2017-04-30

Terbitan

Vol 15 No 1 (2017): JIFI

Bagian

Articles

Lisensi

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