Synthesis and Structure Elucidation of 1,3 bis(p-Hydroxyphenyl)urea

Penulis

  • HARI PURNOMO UNIVERSITAS GADJAH MADA ,
  • UMAR ANGGARA JENIE UNIVERSITAS GADJAH MADA ,
  • AGUNG ENDRO NUGROHO UNIVERSITAS GADJAH MADA ,
  • HARNO DWI PRANOWO UNIVERSITAS GADJAH MADA ,

Kata Kunci:

1.3bis (p - hydroxyphenyl)urea, synthesis, IR, 1H-NMR, 13C-NMR and mass spectroscopic analysis, paracetamol

Abstrak

Parasetamol adalah analgetika-antipiretika yang sering digunakan. Parasetamol memiliki kelemahan efek samping hepatotoksik jika dikonsumsi untuk waktu yang lama atau dosis yang berlebih (10-15 g dosis tunggal). Senyawa 1,3 bis (p-hidroksifenil)urea (selanjutnya senyawa diberi kode HP2009) merupakan analgesik yang diprediksi mempunyai efek samping hepatotoksisitas lebih rendah dibanding parasetamol. Senyawa HP2009 telah berhasil disintesis. Hasil penelitian menunjukkan bahwa reaksi sempurna memerlukan waktu penguapan 30 menit; rasio mol p-aminofenol:urea = 2:9,5; pada pH 1 dan waktu refluks 1 jam mendapatkan hasil 99,49%. Kristal yang diperoleh dikarakterisasi menggunakan metode spektroskopi dan tidak diragukan lagi menunjukkan bahwa produk adalah 1,3 bis (p-hidroksifenil)urea .

Referensi

Unduhan

Diterbitkan

2017-09-04

Terbitan

Vol 14 No 1 (2016): JIFI

Bagian

Articles

Lisensi

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