Isolasi Senyawa Depside-Depsodone dari Lichen Sumatera (Stereocaulon halei) dan Uji Aktivitas Antimikroba serta Anti Tuberkulosis

Penulis

  • FRIARDI ISMED UNIVERSITAS ANDALAS ,
  • SRI HARTATI UNIVERSITAS ANDALAS ,
  • RAMA MULYADI UNIVERSITAS ANDALAS ,
  • HANIF ERONI PUTRA UNIVERSITAS ANDALAS ,
  • NAURA PRIMA VIDIAN UNIVERSITAS ANDALAS ,
  • DEDDI P PUTRA UNIVERSITAS ANDALAS ,

Kata Kunci:

isolasi, Lichen, Stereocaulon halei Lamb, anti tuberkulosis, antimikroba

Abstrak

Phytochemical investigation of Sumatran Lichen (Stereocaulon halei Lamb) harvested in Singgalang mountain, West Sumatera, has been done. Depside, atranorin and depsidon, lobaric acid were rapidly isolated and purified from the ethyl acetate extract (15.88 g) yielded 4.6 g and 1.18 g, respectively. The structures of the two compounds were identified by 1H NMR and 13C NMR. Further each extracts and isolated compounds were investigated for their antibacterial activity using agar diffusion method against Gram-positive bacteria (S. aureus, E. faecalis) and Gram-negative bacteria (E. coli, S. thyphosa, S. Typhimurium and P. aureginosa). Antituberculosis activity of each extracted and isolated compounds showed on growth inhibition of M. tuberculosis H37Rv by means of Lowenstein Jensen medium. Lobaric acid and atranorin showed maximum activity against S. aureus and M. tuberculosis H37Rv bacteria with MIC 0.0125% and 5 μg/ mL, respectively

Referensi

Unduhan

Diterbitkan

2017-09-04

Terbitan

Vol 14 No 1 (2016): JIFI

Bagian

Articles

Lisensi

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.