Mikroenkapsulasi Controlled Release Lansoprazol dengan Kombinasi Hydroxy Propyl Methyl Cellulose Phthalate dan Natrium Alginat secara Gelasi Ionotropik

Abstrak

Lansoprazole is a proton pump inhibitor that has been used as an anti-peptic ulcer and demonstrates an effective absorption in the intestine but decomposed by stomach acid. Therefore, it was necessary to use the controlled release system to improve bioavailability. The polymers used for the system was sodium alginate (2%) by adding calcium lactate at a concentration of 5% (Formula I), 7.5% (Formula II), and 10% (Formula III). The microcapsules were prepared using ionotropic gelation method. Sodium alginate and lansoprazole were mixed with a ratio of 3:1, and then dripped into a solution of calcium lactate with a stirring speed of 100 rpm. The resulting microcapsules were washed with distilled water and dried for 4 hours at temperature of 60 °C. The results were then characterized for organoleptic, water content, size distribution, recovery and loading capacity, swelling index and release of active substance. The microcapsules produced had the highest swelling index of 256.89%. Formula I has the smallest microcapsule size distribution in the range from 925 to 1000 μm whereas the largest in Formula III in the range from 1075 to 1150 μm. Formula III has the highest recovery (86.5%).The highest entrapment eficiency (Formula III) was 64.46%. The release of lansoprazole within 8 hours of Formula I, II and II were 87.89%, 68.09% and 57.09%, respectively. The microcapsules exhibited gastroresistance after coating with 5 and 10 % HPMCP solution.