(The Effectiveness of Gambier Extract (Uncaria gambir (Hunter) Roxb.) as Hepatoprotective in Rat (Rattus norvegicus L.) Induced CCl4)

Penulis

  • FAHRI FAHRUDIN INSTITUT PERTANIAN BOGOR ,
  • DEDY DURYADI SOLIHIN INSTITUT PERTANIAN BOGOR ,
  • NASTITI KUSUMORINI INSTITUT PERTANIAN BOGOR ,
  • SRI NINGSIH BPPT ,

Abstrak

The liver function as a detoxification create liver damage and can produce fibrosis condition both acute and chronic. One approach for the treatment of liver fibrosis is used antioxidant of natural materials. Extract of gambier was verified containing phenolic compounds of antioxidants. This research was aimed to evaluate gambier potency as hepatoprotective in animal models of liver fibrosis. Total 45 of male Sprague-Dawley rat were equally divided into nine groups. Consisted of D1 (received gambier 13 mg/200 g bw + CCl4), D2 (gambier 26 mg/200 g bw + CCl4), D3 (gambier 53 mg/200 g bw + CCl4), K+1 (poliphenol 25 mg/kg bw + CCl4), K+2 (mixtured medicine extract 302 mg/kg bw + CCl4), K- (CCl4), KG (gambier 53 mg/200 g bw), KP (coconut oil), KN (normal group). CCl4 (0.1 ml/kg bw) given twice a week. The all samples was administered orally (1 ml/200 g bb) for six consecutive weeks. The analyzed parameters were the activities of liver enzymes, malondyaldehyde and glutathione levels were measured in liver homogenates and histopathology were studied in liver sampels. The result showed that extract of gambier repaired the liver damage. Administered extract of gambier showed that gambier haspotential activity as a hepatoprotector significantly (p<0.05) compared with the negative control (K-). The hepatoprotective activity of gambier extract was more effective in D2 (26 mg/200 g bw).

Referensi

Unduhan

Diterbitkan

2017-09-23

Terbitan

Vol 13 No 2 (2015): JIFI

Bagian

Articles

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