Uji In Vitro dan Studi In Silico Senyawa Turunan n’-benzoylisonicotinohydr

Penulis

  • Ruswanto Ruswanto STIKes BTH Tasikmalaya
  • Nur Rahayuningsih Dept. of Pharmacy, Bakti Tunas Husada Health Science College ,
  • Nur Laeli Dwi Hidayati Dept. of Pharmacy, Bakti Tunas Husada Health Science College ,
  • Ginna Sri Nuryani Dept. of Pharmacy, Bakti Tunas Husada Health Science College ,
  • Richa Mardianingrum Dept. of Pharmacy, Bakti Tunas Husada Health Science College ,

DOI:

https://doi.org/10.35814/jifi.v17i2.703

Kata Kunci:

tuberculosis, in vitro, in silico, N-Benzoylisonicotinohydrazide

Abstrak

Telah dilakukannya penelitian tentang studi in vitro dan in silico senyawa turunan N-Benzoylisonicotinohydrazide. Penelitian ini bertujuan untuk mengetahui bahwa senyawa turunan N’-benzoylisonicotinohydrazide dapat menghambat aktivitas bakteri gram positif, gram negatif dan Mycobacterium tuberculosis, serta mempunyai interaksi yang baik dengan Enoyl-Acyl Carrier Protein Reductase dari Mycobacterium Tuberculosis. Dari uji in vitro dihasilkan bahwa senyawa N’-benzoylisonicotinohydrazide memiliki Minimum Inhibitor Concentration (MIC) sebesar 0,33 µg/ml terhadap bakteri Basillus subtilis, sedangkan besarnya Minimum Inhibitor Concentration (MIC) senyawa N’-(2-chlorobenzoyl)isonicotinohydrazide terhadap Mycobacterium tuberkulosis (H37Rv) adalah sebesar 3,125 µg/ml. Dari studi in silico didapat bahwa nilai binding affinity antara senyawa N’-(2-chlorobenzoyl)isonicotinohydrazide enzim Enoyl-Acyl Carrier Protein Reductase (2X23) mempunyai binding affinity yang paling kecil sehingga dapat diprediksi bahwa senyawa tersebut mempunyai interaksi yang stabil dan paling baik disbanding senyawa-senyawa lainnya sehingga senyawa N’-(2-chlorobenzoyl)isonicotinohydrazide dapat digunakan sebagai kandidat antituberkulosis yang lebih poten.

Referensi

Unduhan

Diterbitkan

2019-10-29

Terbitan

Vol 17 No 2 (2019): JIFI

Bagian

Articles

Lisensi

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