Isolasi dan Identifi kasi Senyawa Fenolik dari Daun Macaranga hispida Blume Mull.Arg

Penulis

  • Megawati Megawati Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,
  • Sofa Fajriah Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,
  • Galuh Widyawati Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,
  • Akhmad Darmawan Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong ,

DOI:

https://doi.org/10.35814/jifi.v18i2.722

Kata Kunci:

Macaranga hispida, senyawa fenolik, asam galat, metil galat, sitotoksisitas

Abstrak

Kelanjutan penelitian pada tanaman Macaranga telah dilakukan. Pada penelitian ini dilakukan
kandungan fenol total dari ekstrak daun Macaranga hispida Blume Mull.Arg. Asam galat (1) dan metil
galat (2) telah diisolasi dari fraksi etil asetat yang memiliki kandungan fenolik tertinggi (8,41 mg GAE
/g). Serangkaian teknik kromatografi dan spektroskopi yaitu ekstraksi, fraksinasi, pemurnian, FTIR,
LCMS, dan FT-NMR digunakan untuk mengisolasi dan identifi kasi isolat. Sitotoksisitas senyawa 1 dan
2 terhadap sel murine leukimia P-388 menunjukkan bahwa senyawa 2 memiliki aktivitas antikanker
yang lebih tinggi dibandingkan dengan senyawa 1 dengan nilai IC50 75,53 μg/mL.

Referensi

Unduhan

Diterbitkan

2020-10-28

Terbitan

Vol 18 No 2 (2020): JIFI

Bagian

Articles

Lisensi

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.